2. Cytotoxicity and Biocompatibility of Direct and Indirect Pulp Capping Materials
Karin Cristina da Silva MODENA1, Leslie Caroll CASAS-APAYCO1, Maria Teresa ATTA2, Carlos Alberto de Souza COSTA3, Josimeri HEBLING4, Carla Renata SIPERT5, Maria Fidela de Lima NAVARRO6, Carlos Ferreira SANTOS7
1- DDS, Graduate student, Department of Operative Dentistry, Endodontics and Dental Materials, University of São Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
2- DDS, MSc, PhD, Associate Professor, Department of Operative Dentistry, Endodontics and Dental Materials, University of São Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
3- DDS, MSc, PhD, Associate Professor, Department of Physiology and Pathology, State University of São Paulo, Araraquara Dental School, Araraquara, SP, Brazil.
4- DDS, MSc, PhD, Associate Professor, Department of Orthodontics and Pediatric Dentistry, State University of São Paulo, Araraquara Dental School, Araraquara, SP, Brazil.
5- DDS, MSc, Graduate student, Department of Biological Sciences, University of São Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
6- DDS, MSc, PhD, Full Professor, Department of Operative Dentistry, Endodontics and Dental Materials, University of São Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
7- DDS, MSc, PhD Associate Professor, Department of Biological Sciences, University of São Paulo, Bauru School of Dentistry, Bauru, SP, Brazil.
Corresponding address: Maria Teresa Atta, Disciplina de Dentística – Alameda Dr. Octávio Pinheiro Brizolla, 9-75 – 17012-901 – Vila Cidade Universitária – Bauru, SP – Brazil – Fone: +55-14-3235-8358 – Fax: +55-14-3235-8523 – E-mail: tereatta@usp.br
Received: October 8, 2008 – Modification: January 19, 2009 – Accepted: 27 May, 2009
Abstract
There are several studies about the cytotoxic effects of dental materials in contact with the pulp tissue, such as calcium hydroxide (CH), adhesive systems, resin composite and glass ionomer cements. The aim of this review article was to summarize and discuss the cytotoxicity and biocompatibility of materials used for protection of the dentin-pulp complex, some components of resin composites and adhesive systems when placed in direct or indirect contact with the pulp tissue. A large number of dental materials present cytotoxic effects when applied close or directly to the pulp, and the only material that seems to stimulate early pulp repair and dentin hard tissue barrier formation is CH.
Key words: Cytotoxicity. Dental pulp capping. Fibroblasts. Odontoblasts.
J Appl Oral Sci. 2009 Nov-Dec;17(6):544-54.